Buy deca durabolin online acts locally in the lung tissue, so its content in blood plasma is an indicator of no therapeutic effects. Data on the pharmacokinetics of its very limited due to technical problems: during inhalation of therapeutic doses of its maximum concentration in plasma is extremely low (200 pg / ml and below). After regular inhaled salmeterol in the blood can be detected gidroksinaftoevuyu acid, the equilibrium concentration of about 100 ng / ml. These concentration 1000 times lower than the equilibrium concentration observed in the toxicity studies. There were no adverse effects with long-term regular use of the drug (for more than 12 months) in patients with airway obstruction patients.
Fluticasone propionate: Absolute bioavailability of inhaled fluticasone propionate in healthy individuals varies depending on the inhaler, when administered a combination of salmeterol and fluticasone propionate by inhaler . In patients with asthma and chronic obstructive pulmonary disease are observed lower concentrations of fluticasone propionate in plasma. Systemic absorption occurs predominantly through the lungs. At first it faster, but then it slows down the speed.
Some inhaled dose may be swallowed, but this part is making a minimal contribution to the systemic absorption due to the low solubility of fluticasone propionate in water and because of its first-pass metabolism; bioavailability from the gastrointestinal tract is less than 1%. As the inhalation dose observed linear increase in the concentration of fluticasone propionate in plasma.
no data on the distribution of salmeterol. Fluticasone propionate has a high volume of distribution at steady state (approximately 300 L) and has a relatively high degree of binding to plasma proteins (91%).
study results in vitro showed that salmeterol is extensively metabolized by the action of buy deca durabolin online of cytochrome and up-gidroksisalmeterola by aliphatic oxidation. When repeated dosing study with salmeterol and erythromycin in healthy volunteers no clinically significant changes pharmaco dynamic effects while taking erythromycin 500 mg 3 times a day. However, the study of salmeterol and ketoconazole interaction showed a significant increase salmeterol plasma concentration.
Fluticasone propionate is rapidly eliminated from the blood, mainly as a result of metabolism by the action of the isoenzyme cytochrome system to an inactive metabolite carboxy. Care must be taken while the application of known inhibitors of buy deca durabolin online and fluticasone propionate, because these situations may increase the content of the latter in plasma.
No data concerning the excretion of salmeterol. Distribution fluticasone propionate is characterized by rapid clearance from the plasma and final half-life of approximately 8 hours. The renal clearance of fluticasone propionate unmodified negligible as a metabolite in the urine output of less than 5% of the dose.
Indications for use:
Drug Seretide Multidisk for the regular treatment of asthma, if combination therapy is a beta 2 -adrenomimetikom long-acting inhaled corticosteroid:
– patients with poor control of the disease against a background of continuing monotherapy with inhaled corticosteroids with occasional use of beta 2 – adrenomimetic short-acting or
– patients with adequate control of the disease on therapy with an inhaled corticosteroid and beta 2 -adrenomimetikom long-acting, or
– as a starting maintenance therapy in patients with persistent asthma in the presence of indications for use of glucocorticosteroids to achieve control of the disease.
Drug Seretide Multidisk for maintenance therapy in patients , with a value of forced expiratory volume buy deca durabolin online of predicted values (up to inhaled bronchodilator) and a history of repeated exacerbations in whose disease severe symptoms persist despite regular bronchodilator therapy.