The safety and efficacy of Seroquel have not been established in pregnant women. Therefore, during pregnancy, Seroquel can only apply if the expected benefit justifies the potential risk.The degree of excretion of quetiapine with human milk is not known. Women should be advised to avoid breast-feeding while taking deca durabolin dosage.
DOSAGE AND ADMINISTRATION
Seroquel is assigned to 2 times a day by mouth, regardless of the meal.
Treatment of acute and chronic psychoses, including schizophrenia
The daily dosage for the first 4 days of therapy, is as follows: Day 1 – 50 mg, 2 day – 100 mg, 3 day – 200 mg, Day 4 – 300 mg. From the 4th day, the dose should be titrated to an effective dosage is typically in the range of 300 to 450 mg / day. Depending on the clinical response and tolerance of the individual patient, the dose can vary from 150 to 750 mg / day.
Treatment of manic episodes of bipolar disorder in the structure
Seroquel is used as monotherapy or as adjunctive therapy to mood stabilization.
The daily dosage for the first 4 days of treatment: 1 day – 100 mg, 2 day – 200 mg, 3 day – 300 mg, Day 4 – 400 mg. Subsequently, by the 6th day of treatment the daily dose can be increased to 800 mg.Increasing the daily dose should not exceed 200 mg per day.
Depending on the clinical effect and individual tolerability, the dose can vary from 200 to 800 mg / day. Typically, the effective dose is from 400 to 800 mg / day.
For the treatment of schizophrenia, the maximum recommended daily dose is 750 mg of quetiapine in the treatment of manic episodes of bipolar disorder in the structure of the maximum recommended daily is 800 mg / day.
In elderly patients, an initial dose of deca durabolin dosage is 25 mg / day. Daily dose should be increased to 25 50 mg to achieve an effective dose which is likely to be smaller than in younger patients.
Patients with renal and hepatic insufficiency
In patients with renal or hepatic impairment it is recommended to start treatment with quetiapine 25 mg / day. It is recommended to increase the dose of 25-50 mg daily to achieve an effective dose.
Children and adolescents
The safety and efficacy of Seroquel in children and adolescents has not been investigated.
Noted the following common adverse reactions associated with the administration of the drug: drowsiness (17.5%), dizziness (10%), constipation (9%), dyspepsia (6%), orthostatic hypotension and tachycardia (7%), dry mouth ( 7%) increase in serum liver enzymes (6%) (including increased concentrations of cholesterol and triglycerides).
Quetiapine may be accompanied by the development of mild asthenia, rhinitis and dyspepsia, weight gain (especially in the first weeks of treatment).
Seroquel may cause orthostatic hypotension (dizziness accompanied by), tachycardia, and in some patsientov- fainting; These adverse reactions generally occur during the initial dose-titration period (see. “Special Instructions” section).
In patients treated with deca durabolin dosage, were very rare cases of priapism and the occurrence of seizures.
In rare cases, there neuroleptic malignant syndrome (hyperthermia, altered mental status, muscular rigidity, vegetative-vascular disorders, increasing the concentration of creatine phosphokinase), observed leucopenia and / or neutropenia. There were no cases of severe neutropenia or agranulocytosis in patients taking Seroquel. If you are using Seroquel in general practice leukopenia and / or neutropenia resolved after discontinuation of the drug. Possible risk factors for leucopenia and / or neutropenia include a reduction in the number of white blood cells before treatment, or available in the anamnesis on leukopenia and / or neutropenia caused by taking drugs. Occasionally there have been cases of eosinophilia, the development of peripheral edema, allergic reactions, including angioedema.
Reported cases of asymptomatic increase in serum transferases (alanine and aspartic respectively), or the activity of gamma-glutamyl transferase , in patients taking Seroquel. The treatment of these changes quetiapine were usually reversible.
During treatment with quetiapine may experience a slight increase in serum cholesterol and triglycerides.
Treatment with quetiapine associated with a small dose-dependent decrease in the level of thyroid hormones, in particular, total and free . The maximum decrease in total and free was registered on the 2nd and 4th week of therapy with quetiapine, without further reducing the concentration of hormones during prolonged treatment. In the future, there was no evidence of clinically relevant changes in the concentration of thyroid-stimulating hormone.
In almost all cases, the deca durabolin dosage concentration of total and free returned to baseline after discontinuation of quetiapine therapy, regardless of the duration of treatment. Seroquel may cause prolongation of the interval , the use of Seroquel relationship with the steady increase is not identified .
high blood pressure, palpitations, dysarthria, pharyngitis, cough, anorexia, increased sweating. The causal relationship of side effects data with quetiapine has not been established.