Absorption of sertraline from the gastrointestinal tract significantly, but is slow. Maximum plasma concentration is achieved through 4,5-8,4 hours after ingestion of the drug. The equilibrium concentration of sertraline in blood plasma is achieved within a week for a single daily reception. Bioavailability during meal increased by 25%, the time to maximum concentration is shortened.
Distribution. Total binding of sertraline to plasma proteins is 98%. The volume of distribution deca durabolin price.
Metabolism and excretion. Sertraline is extensively metabolized during the first passage through the liver, subjected to N-demethylation. Its main metabolite – N-desmetilsertralin less active as compared to the parent compound. The metabolites are excreted with urine and faeces in equal amounts. About 0.2% of sertraline excreted by the kidneys unchanged. Half-life time is 22-36 hours, regardless of age or sex.
The half-life of sertraline time and area under the plasma concentration curve increase with abnormal liver function. Regardless of the severity of renal failure the pharmacokinetics of sertraline in his constant use is not changed.
Sertraline passes into breast milk. Data about its ability to pass through the blood-placental barrier there. Sertraline is not dialyzed.
Indications for use :
- Depression different etiology (treatment and prevention)
- Obsessive-Compulsive Disorder
- Panic disorder (with or without agoraphobia).
- Post-traumatic stress disorder .
- Hypersensitivity to the active substance or any other ingredients in the drug,
- concomitant use of sertraline and deca durabolin price inhibitors. When replacing one drug to another should avoid antidepressants within 14 days,
- concomitant use of sertraline with tryptophan or fenfluramine
- unstable epilepsy,
- Children under 6 years of age;
- pregnancy and lactation (see. “Special Instructions”).
Precautions : organic brain disease (including mental retardation), manic state, epilepsy, liver and / or kidney failure, weight loss, in children older than 6 years.
Dosing and Administration
Adults The initial dose is 50 mg sertraline once a day, morning or evening. The daily dose can be gradually, not earlier than one week increased to 50 mg, to a maximum daily dose of 200 mg.
Initial dose is 25 mg sertraline once a day, morning or evening. A week later, the doctor can increase the dose to 50 mg of sertraline once a day, and then gradually, not earlier than one week, the daily dose can be gradually increased from 50 mg up to a maximum daily dose of 200 mg.
A satisfactory therapeutic results achieved typically after 7 days from the start of treatment. However, to achieve full therapeutic effect requires regular intake of the drug for 2-4 weeks. Patients with obsessive-compulsive disorder to achieve a good result may require 8-12 weeks. The minimum dose that provides the therapeutic effect is retained in the future as a support. Children with deca durabolin price for children from 6 to 12 years, the starting dose is 25 mg sertraline once a day, morning or evening. After one week, the dose can be increased to 50 mg once a day. For children aged 12 to 17 years of the initial dose is 50 mg once a day, in the morning or evening. The daily dose can be gradually, not earlier than one week increased to 50 mg, to a maximum daily dose of 200 mg. To avoid overdose, consideration should be given less weight in children than adults, and by increasing the dose of 50 mg / day should be carefully monitored for this category of patients and stop the drug at the first sign of overdose.