Injectable deca durabolin for sale combined medication that contains salmeterol and fluticasone propionate which have different mechanisms of action. Salmeterol prevents bronchospasm symptoms, fluticasone propionate improves lung function and prevents exacerbations. Drug Seretide Multidisk due to more convenient dosing regimen may be an alternative for patients who receive both agonist beta 2 adrenoceptor and inhaled glucocorticosteroids (GCS) of different inhalers. Salmeterol – a selective long-acting (up to 12 hrs) agonist beta 2 -adrenoceptor having a long side chain which binds to the receptor domain naruzhnm.
The pharmacological properties of salmeterol offer more effective protection against histamine-induced bronchoconstriction and longer lasting bronchodilation (lasting at least 12 hours) than the agonists beta2 adrenoceptor short-acting.
In vitro studies showed that salmeterol is a potent inhibitor of the release of human lung mast cell mediators, such as histamine, leukotriene and prostaglandin , and has a prolonged period.
Salmeterol inhibits the early and late phase response to inhaled allergens. The inhibition of the late phase response is maintained for more than 30 hours after administration of a single dose at the time when the bronchodilatory effect is no longer present.
A single administration of salmeterol attenuates bronchial hyper-responsiveness of the tree. This suggests that in addition to the bronchodilator salmeterol activity has dopolnitelnm action not related to the expansion of the bronchi, the clinical significance of which is not completely installed. This mechanism of action differs from the anti-inflammatory effect of injectable deca durabolin for sale.
Fluticasone propionate belongs to the group of corticosteroids for topical and inhalational administration at recommended doses has a significant anti-inflammatory and antiallergic action in the lungs, resulting in reduction of clinical symptoms, reducing the incidence of exacerbations of asthma. Fluticasone propionate causes adverse events that occur with systemic corticosteroids.
With prolonged use of inhaled fluticasone propionate daily secretion of adrenal hormones remained in the normal range in both adults and children, even when using the maximum recommended dose. After the transfer of patients treated with other inhaled corticosteroids, to receive fluticasone propionate daily secretion of adrenal hormones is gradually improving, in spite of the previous and current periodic use of oral steroids. This indicates a recovery of adrenal function on the background of the use of inhaled fluticasone propionate. With prolonged use of fluticasone propionate backup function of the adrenal cortex also remained within normal limits, as evidenced by an increase in the normal production of cortisol in response to appropriate stimulation (please note that the reduction in residual adrenal reserve, caused by previous therapy can be maintained for a long time).
No evidence that the co-administration of inhaled salmeterol and fluticasone propionate affect the pharmacokinetics of each other, and therefore, the pharmacokinetic characteristics of each component drug Seretide Multidisk can be considered separately.
A study involving 15 healthy volunteers who simultaneously received salmeterol (inhalational administration of 50 mg twice a day), and inhibitor of isozyme (oral administration of 400 mg once daily) for 7 days showed a significant increase salmeterol concentration plasma injectable deca durabolin for sale. There was no increase in salmeterol accumulation when receiving repeated doses. In 3 patients the treatment was canceled due to prolongation or palpitations with sinus tachycardia. In the remaining 12 patients the simultaneous use of salmeterol and ketoconazole did not have a clinically significant effect on heart rate, level of potassium in the blood, or the duration of the interval . online anabolic steroids pharmacy
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